At the risk of jumping in the middle, I think I get what he is referring to. He is pointing out that if you know that you will have to use HV during part of your trip, it's more efficient to do the HV portion of the trip above 46 mph and the EV portion below 46 mph whenever possible, as a way to maximize the amount of direct drive HV as opposed to electricity generating HV. In other words if it's a 125 mile trip and you have 50 miles EV range, then you expect that about 75 miles of the trip will be in HV. Following what he is saying your goal is to have as many of those 75 HV miles to be in direct drive mode as possible, which can be accomplished by doing as much of the HV driving as possible above 46 mph, and using EV for speeds below that. Of course how much you can use EV below 46 mph will depend on how many EV miles you have available. If you are getting low on EV miles (or reach 0) then of course you will need to use HV even below 46 mph. Also you want to eventually use up all of your EV miles by the end of the trip, so in some cases you may need to use EV above 46 mph in order to use it up.
By the way I think I have heard of the 46 mph direct drive minimum before, but I don't think I have paid enough attention to notice if that's the exact cut-off when I am driving in HV.
The idea behind all of this is that the engine in direct drive is more efficient than when it's generating electricity which has to be transferred to the electric motor, leading to some inevitable losses. Although I have heard opinions that the losses aren't all that much. But without any actual data we can only guess how much efficiency difference there might be.
I do the same thing in principle, just not to that level of detail. When I know I will be doing some HV on a trip I try to do the HV portion on the freeway, and EV on surface streets. For me freeway driving is almost always well over 46 mph (unless heavy traffic) and surface street speed limits in my area are usually 45 mph, although on those I usually go about 50.
In theory if I am on a trip where I know I need to use some HV, and if during the freeway portion of the trip traffic slows below 46 for some reason, I could switch to EV, then when traffic speeds back up again switch back to HV. And if during the surface street portion of the trip if I am driving at 50 I could switch to HV, then when I slow back down below 46 switch back to EV. Adding that extra bit of finesse would probably eke out some additional efficiency gain, but for me that's too much micromanaging. Now there's nothing wrong with micromanaging, it only becomes a problem when someone micromanages other people. But if someone wants to micromanage their car I say go for it if that's what they like doing and if it leads to some efficiency gains. It's all relative really, there are people who think that we are micromanaging our cars by using the HV button at all, their philosophy is just drive the car it will figure it out. Can't argue with that either, if they prefer driving that way and don't mind the engine noise when they run out of EV miles halfway through the trip, good for them, even though I suspect they might give up a little bit of efficiency, but if they prefer driving that way that's okay.
As for me I don't mind pushing a few buttons every once in a while but I have my limits. The great thing about the Clarity is that you can drive it however you want, either as a hypermiler, or as a carefree ne'er-do-well, or somewhere in the middle, either way it will be still be efficient, even if to somewhat varying degrees.