I just keep it in Sport mode or normal mode for highway driving, especially long distances. Then I haven't really noticed a lack of pickup.
For normal mode, I mean when you turn off Eco mode, but don't turn on Sport mode.
It's the same amount of power in all three modes, they just map the accelerator pedal movement differently to give a different feel. Econ mode you have to move the accelerator pedal the farthest to get maximum power, Sport mode the least. Normal mode is in between.
One advantage of Econ mode is that you have to press the pedal past the detent or "click" before ICE comes on. That makes it easier to avoid accidentally turning on ICE during harder acceleration. In Sport mode ICE will come on well before reaching the detent, and thus it's much easier to accidentally kick it on.
Some people use Sport mode on the highway in HV mode, since in that case you aren't worried about activating ICE since it's already on. Some like obermd turn it on briefly during higher power demand situations. Other people keep it in Sport Mode all the time because they like the fact that it will stay in four chevron regen for the duration of the drive, unlike Econ and Normal where four chevron regen goes away once you press the gas pedal. So this means you only have to use the paddles at the beginning of the drive to set regen at four chevrons and it will stay there, unlike Econ and Normal where it keeps resetting regen back to one chevron, and you have to use the paddles every time you slow down if you want higher regen.