There is a lot going on with airflow around the Clarity wheels. Probably most owners know this but for those who don't the scoop on the rear doors is not the typical fake scoops that cars often have, these scoops actually take in air and direct it over the rear wheels, creating an air curtain which reduces turbulence. If you look in the forward part of the rear wheel well you can see the exit where the air comes out, the opening is actually in the back part of the rear door. When I am showing this to people I stick my hand into the scoop and then into the exit in the wheel well to show that this is a real air scoop. You can also shine a flashlight through to demonstrate this. Also if you open the rear door and put your eye up to the opening you can see right through it.
Not everyone knows this but the front also has a scoop, it's just not as visible as the rear scoop. It's in the very lowest left and right corners of the front bumper, you kind of have to bend down to see them. The exit is in the forward part of the wheel well similar to the rear wheels. Again a flashlight shining through the openings helps to see this, obviously better at night or in your garage.
Then of course there are the infamous rear fender skirts, which some people think was just a misguided design idea, but in fact they help control the airflow over the rear wheels. Skirts for the front wheels would probably also be effective but of course it's not practical since the front wheels have to turn.
Last but not least are the aerodynamic wheel covers, which according to Honda do help somewhat with reducing drag. As for the covers being directional, in theory they work better on one side of the car than the other but presumably the difference, if any, is small enough that it doesn't make it worth stocking two different parts.